Genetics & Genomics

3+ day, 2+ hour ago   (338+ words) GLOBAL: Researchers have uncovered a previously unknown gene causing resistance to a leading blood cancer drug and several genes that accelerate lymphoma growth by using a powerful new CRISPR activation library. Traditional CRISPR is a genetic engineering tool that allows…...

6+ day, 7+ hour ago   (307+ words) | Newswise Newswise A Small Molecular Module Helps Time Development Newswise — For an animal to develop normally, cells must not only become the right types, they must do so at the right time. In the worm C. elegans, the protein LIN28 has…...

1+ week, 3+ hour ago   (114+ words) BAM file in genome coordinates Slower; hours per sample at standard settings Fast; minutes per sample Novel splice junction detection A decision framework for choosing a normalization method in RNA-seq analysis: Testing 20,000 or more genes simultaneously at a nominal p-value…...

1+ week, 4+ day ago   (128+ words) Table 1: Summary of contamination types in NGS data, with characteristic data signatures and recommended analytical detection tools. Reads with unexpected or mismatched index combinations Unique dual index audit, per-library read-count review A systematic approach for evaluating a sample flagged for…...

1+ week, 4+ day ago   (385+ words) Purple Pak Choi’s Hidden Genetic Gift: A Borrowed Gene From a Distant Relative Unlocks Anthocyanin Richness | Newswise Newswise Purple Pak Choi’s Hidden Genetic Gift: A Borrowed Gene From a Distant Relative Unlocks Anthocyanin Richness Fine mapping of the BraMYB114 gene…...

1+ week, 4+ day ago   (156+ words) Mapped 5' start position Mapped start position and UMI sequence Distinguishes independent molecules at the same position Appropriate for WGS germline variant calling Yes, with added overhead Appropriate for deep targeted panel sequencing No; removes genuine fragments Yes, via consensus calling…...

1+ week, 4+ day ago   (214+ words) Table 1: Common control types in NGS experiments, their diagnostic purpose, and the failure mode each detects. Benchmarks variant calling against an established truth set Run-level instrument failure or cluster density issues Figure 1: In a confounded design, condition and batch are…...

1+ week, 4+ day ago   (418+ words) Mirage News The University of Exeter has collaborated with Google DeepMind, becoming among the first researchers in the world to test a new platform which contain predictions for the effects of 9 billion genetic variants - every single letter change in the…...

1+ week, 5+ day ago   (327+ words) | Newswise Newswise How a Single Gene Decides Whether a Wax Gourd Grows Long or Round Proposed model for BhSUN-mediated regulation of fruit shape in wax gourd. Newswise — Wax gourd is a widely cultivated cucurbit crop valued for its culinary and…...

1+ week, 5+ day ago   (1625+ words) This is absolutely stunning! Just now, Google DeepMind officially released its major "Alpha" achievement — the AlphaGenome Atlas. It is a searchable predictive database empowered by cutting-edge AI that covers the entire genome. It has completed an unprecedented project in the…...