1+ week, 4+ day ago   (625+ words) Practical recommendations on the evaluation and work-up of sinonasal masses have been published as part of a new multidisciplinary consensus statement, with the aim of reducing diagnostic errors, avoiding inappropriate biopsy and improving the multidisciplinary management of patients with suspected…...

2+ week, 2+ day ago   (666+ words) A novel seven-joint ultrasound score demonstrates high specificity for psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA), with diagnostic performance comparable to existing ultrasound scoring systems but requiring fewer joints for assessment, a new study has shown. Musculoskeletal ultrasound is increasingly…...

1+ mon, 1+ week ago   (834+ words) Weekly subcutaneous obexelimab significantly prolongs time to disease flare, increases remission rates and reduces glucocorticoid requirements compared with placebo in patients with active immunoglobulin G4-related disease (IgG4-RD), a new trial has shown. IgG4-RD is a chronic, systemic fibroinflammatory condition characterised…...

1+ mon, 2+ week ago   (589+ words) Repeated antibiotic exposure in early childhood may disrupt the developing gut microbiome and increase the risk of later inflammatory bowel disease (IBD), with the strongest association observed for Crohn’s disease, according to a recent study. The incidence of childhood-onset IBD…...

2+ mon, 1+ week ago   (235+ words) While frailty is more common in women with acute MI, its association with mortality and adverse outcomes appears stronger in men, study finds....

2+ mon, 1+ week ago   (545+ words) A five-year, £3m research programme, led by King’s College London, aims to tackle one of the most persistent and under-recognised challenges in inflammatory arthritis: chronic pain. Inflammatory arthritis encompasses a range of autoimmune conditions, including rheumatoid arthritis, psoriatic arthritis and axial…...

2+ mon, 2+ week ago   (469+ words) Most systemic psoriasis treatments carry similar risks of serious infection, long-term registry data suggest, although risankizumab is associated with a lower risk than some comparators in recurrent-event analyses. Systemic therapies for psoriasis alter immune function and may increase susceptibility to…...

2+ mon, 2+ week ago   (430+ words) The use of a funnel-shaped intra-abdominal mesh during permanent colostomy formation after rectal cancer surgery significantly reduces parastomal hernia rates over three years without increasing complications, according to long-term randomised trial data. Parastomal hernia is one of the most common…...

2+ mon, 4+ week ago   (509+ words) Distinct genetic patterns shaping body mass index (BMI) from infancy to adolescence have been linked to later-life risk of metabolic disease in a recent analysis, highlighting potential windows for early prevention. Childhood BMI is known to be a strong predictor…...

3+ mon, 4+ day ago   (511+ words) Imaging is more sensitive than physical examination for nodal staging of cutaneous squamous cell carcinoma (cSCC), although its performance is reduced in immunosuppressed patients, according to a recent Spanish study. Early detection of nodal metastases is critical in high-risk cSCC,…...